Clinical Epidemiology and Ageing

[Can positron emission tomography assessment of response to treatment help to individualize use of erlotinib in non-small cell lung cancer?]

Hureaux J, Couturier O, Lacœuille F, Bouchet F, Chouaid C, Saulnier P, Urban T Rev Mal Respir. 2016;33(9):817-823.

<p>Erlotinib can be prescribed in the treatment of locally advanced or metastatic non-small lung cancer cell (NSCLC) after failure of at least one prior chemotherapy regimen on the basis of the BR-21 study. Several publications have recently questioned these results. The metabolic imaging of solid tumours by positron emission tomography is a research field that could help customize the treatment of NSCLC and so complement the treatment approaches allowed by genetic analyses. This strategy is part of an innovative "early metabolic look" approach. The primary objective of this study is to determine if metabolic progression observed between the 7th and 14th day after initiation of treatment with erlotinib by 3'-Deoxy-3'-[18F]-Fluorothymidine PET in patients with EGFR naive NSCLC is predictive for morphological progression after 6 to 8 weeks of treatment. A health economic analysis will be conducted. This study is particularly innovative because it begins the exploration of the era of metabolic evaluation of therapeutic response in NSCLC.</p>

MeSH terms: Biomarkers, Pharmacological; Carcinoma, Non-Small-Cell Lung; Drug Monitoring; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Male; Positron-Emission Tomography; Precision Medicine; Predictive Value of Tests; Research Design; Treatment Outcome
DOI: 10.1016/j.rmr.2016.03.009