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Clinical Epidemiology and Ageing

The mini mental state examination at the time of Alzheimer's disease and related disorders diagnosis, according to age, education, gender and place of residence: a cross-sectional study among the French National Alzheimer database.

Pradier C, Sakarovitch C, Le Duff F, Layese R, Metelkina A, Anthony S, Tifratene K, Robert P PLoS One. 2014;9(8):e103630.

THE AIM OF THIS STUDY: was firstly to describe the MMSE (Mini-Mental State Examination) score upon initial diagnosis of Alzheimer's disease and related disorders among the French population, according to age. Secondly, education, gender and place of residence were studied as factors potentially associated with delayed Alzheimer's disease diagnosis.

DESIGN: we conducted a cross sectional analysis of the French National Alzheimer database (BNA). Data from 2008 to 2012 were extracted. Patients were selected at the moment of their first diagnosis of AD (n = 39,451).

RESULTS: The MMSE score at initial diagnosis dropped significantly with increasing age. The test score increased with the degree of educational background regardless of age. Gender and place of residence were significantly related to the MMSE score, women and persons living in medical institutions having lower MMSE scores under the age of 90 years and at all educational levels.

CONCLUSIONS: Health care professionals should be aware of these risk factors in order to maximize chances of earliest possible diagnosis of Alzheimer's disease and related disorders.

MeSH terms: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cross-Sectional Studies; Databases, Factual; Delayed Diagnosis; Educational Status; Female; France; Humans; Male; Mental Status Schedule; Middle Aged; Residence Characteristics
DOI: 10.1371/journal.pone.0103630

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