Etienne Audureau
EpidémiologisteProfesseurHDR
Enseignants chercheurs
Santé Publique - Hôpital Henri Mondor
- 1 rue Gustave Eiffel94010 Créteil
Description
Co-directeur équipe INSERM CEpiA, responsable de l'axe "Multimorbidité, Fragilité, Dépendance"
Co-porteur de la Chaire AI-RACLES "Intelligence artificielle pour l’évaluation des profils, trajectoires et prises en charge de la vulnérabilité en santé : COVID-19, fragilité du sujet âgé et cancer"
Responsable de l'Unité de Recherche Clinique Mondor, Chef de service de Santé Publique, Hôpital Henri Mondor, AP-HP
Président de la Collégiale de Santé Publique
Thèmes de recherche
1. Repérage et caractérisation de la vulnérabilité associée au vieillissement
- Repérage de la vulnérabilité des sujets âgés atteints de cancer
- Caractérisation des profils de vulnérabilité et de multimorbidité et élaboration de modèles pronostiques
2. Mesures de qualité de vie et santé perçue en gériatrie
Publications
2024
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Teiger E, Eschalier R, Amabile N, Rioufol G, Ducrocq G, Garot P, Lepillier A, Bille J, Elbaz M, Defaye P, Audureau E, Le Corvoisier P. Left atrial appendage closure in very elderly patients in the French National Registry. Heart. 2024;110(4):245-253.
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Ferrat E, Mirat W, Boutin E, Maroto E, Brossier S, Hoonakker J-D, Audureau E, Phan T-T, Bastuji-Garin S. COVID-19 profiles in general practice: a latent class analysis. BMJ Open. 2024;14(6):e080393.
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Orcel V, Banh L, Bastuji-Garin S, Renard V, Boutin E, Gouja A, Caillet P, Paillaud E, Audureau E, Ferrat E. Effectiveness of comprehensive geriatric assessment adapted to primary care when provided by a nurse or a general practitioner: the CEpiA cluster-randomised trial. BMC Med. 2024;22(1):414.
2023
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Feredj E, Audureau E, Boueilh A, Fihman V, Fourati S, Lelièvre J-D, Gallien S, Grimbert P, Matignon M, Melica G. Impact of a Dedicated Pretransplant Infectious Disease Consultation on Respiratory Tract Infections in Kidney Allograft Recipients: A Retrospective Study of 516 Recipients. Pathogens. 2023;12(1).
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Labbe V, Contou D, Heming N, Megarbane B, Razazi K, Boissier F, Ait-Oufella H, Turpin M, Carreira S, Robert A, Monchi M, Souweine B, Préau S, Doyen D, Vivier E, Zucman N, Dres M, Fejjal M, Noel-Savina E, Bachir M, Jaffal K, Timsit J-F, Picos SAlberto, Mariotte E, Martis N, Juguet W, Melica G, Rondeau P, Audureau E, Dessap AMekontso. Effects of Standard-Dose Prophylactic, High-Dose Prophylactic, and Therapeutic Anticoagulation in Patients With Hypoxemic COVID-19 Pneumonia: The ANTICOVID Randomized Clinical Trial. JAMA Intern Med. 2023;183(6):520-531.
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Jenvrin A, Galletto-Pregliasco A, Audureau E, Pujals A, Favre L, Luciani A, Calderaro J, Sommacale D, Chatellier G, Tournigand C, Laurent A, Kempf E. Intentional R1 resection of liver metastases: A new treatment paradigm for patients with advanced colorectal cancer based on a propensity score-Matched case-control analysis. Clin Res Hepatol Gastroenterol. 2023;47(4):102097.
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Melica G, Bartolucci P, Audureau E, Le Corvoisier P, Habibi A, Gellen J, Selmane D, Michel M, Lacabaratz C, Levy Y. Immunological Efficacy of Pneumococcal Vaccination Including the 13-Valent Pneumococcal Conjugate Vaccine in Adult Patients With Sickle Cell Disease: Results of the Randomized DREVAC Controlled Trial. Clin Infect Dis. 2023;76(11):1949-1958.
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Kharoubi M, Bezard M, Broussier A, Galat A, Gounot R, Poullot E, Molinier-Frenkel V, Fanen P, Funalot B, Itti E, Lemonnier F, Chadha GDeep Sing, Guendouz S, Mallet S, Zaroui A, Audard V, Audureau E, Le Corvoisier P, Hittinger L, Bordeneuve VPlanté, Lefaucheur J-P, Amiot A, Béquignon E, Bartier S, Leroy V, Teiger E, Oghina S, Damy T. Amylo-AFFECT-QOL, a self-reported questionnaire to assess health-related quality of life and to determine the prognosis in cardiac amyloidosis. Front Cardiovasc Med. 2023;10:1124660.
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Pezel T, Dreyfus J, Mouhat B, Thébaut C, Audureau E, Bernard A, Badie YLavie, Bohbot Y, Fard D, Nguyen LS, Monteil C, Bière L, Le Ven F, Canu M, Ribeyrolles S, Mion B, Bazire B, Fauvel C, Cautela J, Cambet T, Le Tourneau T, Donal E, Lafitte S, Magne J, Mansencal N, Coisne A. Effectiveness of Simulation-Based Training on Transesophageal Echocardiography Learning: The SIMULATOR Randomized Clinical Trial. JAMA Cardiol. 2023;8(3):248-256.
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Serrano AGonzález, Laurent M, Barnay T, Martinez-Tapia C, Audureau E, Boudou-Rouquette P, Aparicio T, Rollot-Trad F, Soubeyran P, Bellera C, Caillet P, Paillaud E, Canoui-Poitrine F. A Two-Step Frailty Assessment Strategy in Older Patients With Solid Tumors: A Decision Curve Analysis. J Clin Oncol. 2023;41(4):826-834.
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Boyer L, Zebachi S, Gallien S, Margarit L, Baptista BRibeiro, Lopez-Zaragoza J-L, d'Humières T, Zerah F, Hue S, Derumeaux G, Adnot S, Audureau E, Lelièvre J-D. Combined effects of smoking and HIV infection on the occurrence of aging-related manifestations. Sci Rep. 2023;13(1):21745.
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Damy T, Zaroui A, de Tournemire M, Kharoubi M, Gounot R, Galat A, Guendouz S, Funalot B, Itti E, Roulin L, Audard V, Fanen P, Leroy V, Poulot E, Belhadj K, Mallet S, Chadah GDeep Singh, Planté-Bordeneuve V, Gendre T, Chevalier X, Guignard S, Béquignon E, Bartier S, Folliguet T, Lemonier F, Audureau E, Tixier D, Canoui-Poitrine F, Lefaucheur J-P, Souvannanorath S, Authier F-J, Maupou S, Hittinger L, Molinier-Frenkel V, David J-P, Broussier A, Oghina S, Teiger E. Changes in amyloidosis phenotype over 11 years in a cardiac amyloidosis referral centre cohort in France. Arch Cardiovasc Dis. 2023;116(10):433-446.
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Ladner J, Madi F, Jayasundera R, Saba J, Audureau E. Phone contacts and treatment discontinuation predict survival cancer patients in a subsidized drug access program. J Comp Eff Res. 2023;12(7):e220210.
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Leemans M, Cuzuel V, Bauër P, Aissa HBaba, Cournelle G, Baelde A, Thuleau A, Cognon G, Pouget N, Guillot E, Fromantin I, Audureau E. Screening of Breast Cancer from Sweat Samples Analyzed by 2-Dimensional Gas Chromatography-Mass Spectrometry: A Preliminary Study. Cancers (Basel). 2023;15(11).
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Dreyfus J, Bohbot Y, Coisne A, Lavie-Badie Y, Flagiello M, Bazire B, Eggenspieler F, Viau F, Riant E, Mbaki Y, Eyharts D, Senage T, Modine T, Nicol M, Doguet F, Le Tourneau T, Tribouilloy C, Donal E, Tomasi J, Habib G, Selton-Suty C, Radu C, Lim P, Raffoul R, Iung B, Obadia J-F, Audureau E, Messika-Zeitoun D. Predictive value of the TRI-SCORE for in-hospital mortality after redo isolated tricuspid valve surgery. Heart. 2023;109(12):951-958.
2022
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Youssov K, Audureau E, Vandendriessche H, Morgado G, Layese R, Goizet C, Verny C, Bourhis M-L, Bachoud-Lévi A-C. The burden of Huntington's disease: A prospective longitudinal study of patient/caregiver pairs. Parkinsonism Relat Disord. 2022;103:77-84.
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Damy T, Benedyga V, Pezel T, Berthelot E, Gauthier J, Habib G, Iliou M-C, Aupetit J-F, Baudry G, De Groote P, Logeart D, Chaufourier L, Ciobotaru V, Pousset F, Beauvais F, Bauer F, Zores F, Lairez O, Richard K, Hittinger L, Teiger E, Taieb C, Audureau E. Prescription, Compliance, and Burden Associated with Salt-Restricted Diets in Heart Failure Patients: Results from the French National OFICSel Observatory. Nutrients. 2022;14(2).
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Ladner J, Alshurafa S, Madi F, Nofal A, Jayasundera R, Saba J, Audureau E. Factors impacting self-management ability in patients with chronic diseases in the United Arab Emirates, 2019. J Comp Eff Res. 2022;11(3):179-192.
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Sebti M, Petit-Hoang C, Chami B, Audureau E, Cordonnier-Jourdin C, Paul M, Pourcine F, Grimbert P, Ourghanlian C, Matignon M. ATG-Fresenius increases the risk of red blood cell transfusion after kidney transplantation. Front Immunol. 2022;13:1045580.
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Lemercier P, de Langavant LCleret, Bagnou JHamet, Youssov K, Lemoine L, Audureau E, Massart R, Bachoud-Lévi A-C. Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington's Disease. J Pers Med. 2022;12(2).
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Bauër P, Leemans M, Audureau E, Gilbert C, Armal C, Fromantin I. Remote Medical Scent Detection of Cancer and Infectious Diseases With Dogs and Rats: A Systematic Review. Integr Cancer Ther. 2022;21:15347354221140516.
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Leemans M, Bauër P, Cuzuel V, Audureau E, Fromantin I. Volatile Organic Compounds Analysis as a Potential Novel Screening Tool for Breast Cancer: A Systematic Review. Biomark Insights. 2022;17:11772719221100709.
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Martinez-Tapia C, Laurent M, Paillaud E, Caillet P, Ferrat E, Lagrange J-L, Rwabihama J-P, Allain M, Chahwakilian A, Boudou-Rouquette P, Bastuji-Garin S, Audureau E. Predicting Frailty and Geriatric Interventions in Older Cancer Patients: Performance of Two Screening Tools for Seven Frailty Definitions-ELCAPA Cohort. Cancers (Basel). 2022;14(1).
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Canoui-Poitrine F, Martinez-Tapia C, Paillaud E, Mathoulin-Pelissier S, Pamoukdjian F, Frasca M, Tolppanen A-M, Bringuier M, Brain E, Broussier A, Bastuji-Garin S, Laurent M, Audureau E. Geriatric impairments were directly and indirectly associated with mortality in older patients with cancer: a structural equation analysis. J Clin Epidemiol. 2022;148:17-26.
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Bencheikh L, Nguyen K-A, Chadebech P, Kiger L, Bodivit G, Jouard A, Pakdaman S, Adypagavane S, Audureau E, Tebbakha K, Bocquet T, Mignen B, Hebert N, Seguin M, Pirenne F, Sowemimo-Coker S, Dunham A, Bartolucci P. Preclinical evaluation of the preservation of red blood cell concentrates by hypoxic storage technology for transfusion in sickle cell disease. Haematologica. 2022;107(8):1944-1949.
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Canoui-Poitrine F, Segaux L, Benderra M-A, About F, Tournigand C, Laurent M, Caillet P, Audureau E, Ferrat E, Lagrange J-L, Paillaud E, Bastuji-Garin S. The Prognostic Value of Eight Comorbidity Indices in Older Patients with Cancer: The ELCAPA Cohort Study. Cancers (Basel). 2022;14(9).
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Baptista BRibeiro, d'Humières T, Schlemmer F, Bendib I, Justeau G, Al-Assaad L, Hachem M, Codiat R, Bardel B, Chakra LAbou, Belmondo T, Audureau E, Hue S, Mekontso-Dessap A, Derumeaux G, Boyer L. Identification of factors impairing exercise capacity after severe COVID-19 pulmonary infection: a 3-month follow-up of prospective COVulnerability cohort. Respir Res. 2022;23(1):68.
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Dreyfus J, Audureau E, Bohbot Y, Coisne A, Lavie-Badie Y, Bouchery M, Flagiello M, Bazire B, Eggenspieler F, Viau F, Riant E, Mbaki Y, Eyharts D, Senage T, Modine T, Nicol M, Doguet F, Nguyen V, Le Tourneau T, Tribouilloy C, Donal E, Tomasi J, Habib G, Selton-Suty C, Raffoul R, Iung B, Obadia J-F, Messika-Zeitoun D. TRI-SCORE: a new risk score for in-hospital mortality prediction after isolated tricuspid valve surgery. Eur Heart J. 2022;43(7):654-662.
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Labbe V, Contou D, Heming N, Megarbane B, Ait-Oufella H, Boissier F, Carreira S, Robert A, Vivier E, Fejjal M, Doyen D, Monchi M, Préau S, Noel-Savina E, Souweine B, Zucman N, Picos SAlberto, Dres M, Juguet W, Mariotte E, Timsit J-F, Turpin M, Razazi K, Gendreau S, Baloul S, Voiriot G, Fartoukh M, Audureau E, Dessap AMekontso. Comparison of standard prophylactic, intermediate prophylactic and therapeutic anticoagulation in patients with severe COVID-19: protocol for the ANTICOVID multicentre, parallel-group, open-label, randomised controlled trial. BMJ Open. 2022;12(4):e059383.
2021
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Elkrief L, Lazareth M, Chevret S, Paradis V, Magaz M, Blaise L, Rubbia-Brandt L, Moga L, Durand F, Payancé A, Plessier A, Chaffaut C, Valla D, Malphettes M, Diaz A, Nault J-C, Nahon P, Audureau E, Ratziu V, Castera L, Pagan J-CGarcia, Ganne-Carrié N, Rautou P-E. Liver Stiffness by Transient Elastography to Detect Porto-Sinusoidal Vascular Liver Disease With Portal Hypertension. Hepatology. 2021;74(1):364-378.
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Benjdir M, Audureau E, Beresniak A, Coll P, Epaud R, Fiedler K, Jacquemin B, Niddam L, Pandis SN, Pohlmann G, Sandanger TM, Simmons K, Sørensen M, Wagner P, Lanone S. Assessing the impact of exposome on the course of chronic obstructive pulmonary disease and cystc fibrosis: The REMEDIA European Project Approach. Environ Epidemiol. 2021;5(4):e165.
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Bonnefous L, Kharoubi M, Bezard M, Oghina S, Le Bras F, Poullot E, Molinier-Frenkel V, Fanen P, Deux J-F, Audard V, Itti E, Damy T, Audureau E. Assessing Cardiac Amyloidosis Subtypes by Unsupervised Phenotype Clustering Analysis. J Am Coll Cardiol. 2021;78(22):2177-2192.
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Pezel T, Audureau E, Mansourati J, Baudry G, Ben Driss A, Durup F, Fertin M, Godreuil C, Jeanneteau J, Kloeckner M, Koukoui F, Kesri-Tartière L, Laperche T, Roubille F, Cohen-Solal A, Damy T. Diagnosis and Treatment of Iron Deficiency in Heart Failure: OFICSel study by the French Heart Failure Working Group. ESC Heart Fail. 2021;8(2):1509-1521.
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Fourati S, Langendorf C, Audureau E, Challine D, Michel J, Soulier A, Ahnou N, Désveaux I, Picard O, Ortonne V, Gourgeon A, Mills C, Hemery F, Rieux C, Pawlotsky J-M, Malou N, Chevaliez S. Performance of six rapid diagnostic tests for SARS-CoV-2 antigen detection and implications for practical use. J Clin Virol. 2021;142:104930.
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Pezel T, Berthelot E, Gauthier J, Chong-Nguyen C, Iliou MC, Juillière Y, Galinier MC, De Groote P, Beauvais F, Bauer F, Vergeylen U, Gellen B, Raphael P, Bezard M, Ricci J-E, Boiteux M-C, Bonnefous L, Bodez D, Audureau E, Damy T. Epidemiological characteristics and therapeutic management of patients with chronic heart failure who use smartphones: Potential impact of a dedicated smartphone application (report from the OFICSel study). Arch Cardiovasc Dis. 2021;114(1):51-58.
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Runyo F, Matignon M, Audureau E, Vindrios W, Boueilh A, Gomart C, Grimbert P, Gallien S, Melica G. Infectious disease consultation is effective in boosting vaccine coverage in patients awaiting kidney transplantation: A French prospective study. Transpl Infect Dis. 2021;23(4):e13607.
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Schlemmer F, Zysman M, Baptista BRibeiro, Audureau E, Noroc ACovali, Ridoux A, Derumeaux G, Adnot S, Maitre B, Le Corvoisier P, Lanone S, Boczkowski J, Boyer L. Beclin-1 increases with obstructive sleep apnea severity. Sleep Med. 2021;81:474-476.
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Kharoubi M, Bezard M, Galat A, Le Bras F, Poullot E, Molinier-Frenkel V, Fanen P, Funalot B, Moktefi A, Lefaucheur J-P, Abulizi M, Deux J-F, Lemonnier F, Guendouz S, Chalard C, Zaroui A, Audard V, Béquignon E, Bodez D, Itti E, Hittinger L, Audureau E, Teiger E, Oghina S, Damy T. History of extracardiac/cardiac events in cardiac amyloidosis: prevalence and time from initial onset to diagnosis. ESC Heart Fail. 2021;8(6):5501-5512.
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Verliere A, Clariot S, Pascual-Jouani C, Audureau E, Langeron O, Levesque E. Outcome of asymptomatic patients with positive SARS-CoV-2 viral RNA reverse transcriptase-PCR undergoing surgery: A matched cohort study. Eur J Anaesthesiol. 2021;38(4):442-444.
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Jourdi G, Lobies S, Kosmider O, Duchemin J, Audureau E, Conard J, Mazoyer E, Horellou M-H, Gouin-Thibault I, Flaujac C, Fontenay M. Coagulation Characterization of Prothrombin 20209C > T Variant: About 27 New Cases. Thromb Haemost. 2021;121(2):246-249.
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Pezel T, Bernard A, Badie YLavie, Dreyfus J, Audureau E, Bohbot Y, Fard D, Hubert A, Nguyen LS, Monteil C, Bière L, Le Ven F, Canu M, Ribeyrolles S, Mion B, Mouhat B, Bazire B, Fauvel C, Ternacle J, Cautela J, Cambet T, Le Tourneau T, Donal E, Lafitte S, Mansencal N, Coisne A. Rational and Design of the SIMULATOR Study: A Multicentre Randomized Study to Assess the Impact of SIMULation-bAsed Training on Transoesophageal echocardiOgraphy leaRning for Cardiology Residents. Front Cardiovasc Med. 2021;8:661355.
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Lunven M, Bagnou JHamet, Youssov K, Gabadinho A, Fliss R, Montillot J, Audureau E, Bapst B, Morgado G, Reilmann R, Schubert R, Busse M, Craufurd D, Massart R, Rosser A, Bachoud-Lévi A-C. Cognitive decline in Huntington's disease in the Digitalized Arithmetic Task (DAT). PLoS One. 2021;16(8):e0253064.
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Wind P, Thomas ZAp, Laurent M, Aparicio T, Siebert M, Audureau E, Paillaud E, Bousquet G, Pamoukdjian F. The Pre-Operative GRADE Score Is Associated with 5-Year Survival among Older Patients with Cancer Undergoing Surgery. Cancers (Basel). 2021;14(1).
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Teiger E, Thambo J-B, Defaye P, Hermida J-S, Abbey S, Klug D, Juliard J-M, Spaulding C, Armero S, Champagnac D, Bhugaloo H, Ternacle J, Lellouche N, Audureau E, Le Corvoisier P. Left atrial appendage closure for stroke prevention in atrial fibrillation: Final report from the French left atrial appendage closure registry. Catheter Cardiovasc Interv. 2021;98(4):788-799.
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Nahon P, Layese R, Cagnot C, Asselah T, Guyader D, Pol S, Pageaux G-P, De Lédinghen V, Ouzan D, Zoulim F, Audureau E. HCV Eradication in Primary or Secondary Prevention Optimizes Hepatocellular Carcinoma Curative Management. Cancer Prev Res (Phila). 2021;14(5):581-592.
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Serrano AGonzález, Tapia CMartínez, de la Taille A, Mongiat-Artus P, Irani J, Bex A, Paillaud E, Audureau E, Barnay T, Laurent M, Canoui-Poitrine F. Adherence to Treatment Guidelines and Associated Survival in Older Patients with Prostate Cancer: A Prospective Multicentre Cohort Study. Cancers (Basel). 2021;13(18).
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Oniszczuk J, Beldi-Ferchiou A, Audureau E, Azzaoui I, Molinier-Frenkel V, Frontera V, Karras A, Moktefi A, Pillebout E, Zaidan M, Karoui KEl, Delfau-Larue M-H, Hénique C, Ollero M, Sahali D, Mahévas M, Audard V. Circulating plasmablasts and high level of BAFF are hallmarks of minimal change nephrotic syndrome in adults. Nephrol Dial Transplant. 2021;36(4):609-617.
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Hamon D, Courty B, Leenhardt A, Lim P, Elbaz N, Rouffiac S, Varlet E, Algalarrondo V, Messali A, Audureau E, Extramiana F, Lellouche N. Predictive value of premature atrial complex characteristics in pulmonary vein isolation for patients with paroxysmal atrial fibrillation. Arch Cardiovasc Dis. 2021;114(2):122-131.
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d'Humières T, Savale L, Inamo J, Deux J-F, Deswarte S, Lionnet F, Loko G, Chantalat C, Damy T, Guillet H, d'Orengiani ALaure Pham, Galactéros F, Audureau E, Maitre B, Humbert M, Derumeaux G, Bartolucci P. Cardiovascular phenotypes predict clinical outcomes in sickle cell disease: An echocardiography-based cluster analysis. Am J Hematol. 2021;96(9):1166-1175.
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Deux J-F, Nouri R, Tacher V, Zaroui A, Derbel H, Sifaoui I, Chevance V, Ridouani F, Galat A, Kharoubi M, Oghina S, Guendouz S, Audureau E, Teiger E, Kobeiter H, Damy T. Diagnostic Value of Extracellular Volume Quantification and Myocardial Perfusion Analysis at CT in Cardiac Amyloidosis. Radiology. 2021;300(2):326-335.
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Ganne-Carrié N, Nahon P, Chaffaut C, N'Kontchou G, Layese R, Audureau E, Chevret S. Impact of cirrhosis aetiology on incidence and prognosis of hepatocellular carcinoma diagnosed during surveillance. JHEP Rep. 2021;3(3):100285.
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Kempf E, Lamé G, Layese R, Priou S, Chatellier G, Chaieb H, Benderra M-A, Bellamine A, Bey R, Bréant S, Galula G, Taright N, Tannier X, Guyet T, Salamanca E, Audureau E, Daniel C, Tournigand C. New cancer cases at the time of SARS-Cov2 pandemic and related public health policies: A persistent and concerning decrease long after the end of the national lockdown. Eur J Cancer. 2021;150:260-267.
2020
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Dawidowicz S, Le Breton J, Moscova L, Renard V, Bercier S, Brixi Z, Audureau E, Clerc P, Bastuji-Garin S, Ferrat E. Predictive factors for non-participation or partial participation in breast, cervical and colorectal cancer screening programmes†. Fam Pract. 2020;37(1):15-24.
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Rougier E, Mar W, V Valle D, Morel B, Irtan S, Audureau E, Coulomb-L'Hermine A, H le Pointe D, Blondiaux E. Added value of MRI for the diagnosis of adnexal torsion in children and adolescents after inconclusive ultrasound examination. Diagn Interv Imaging. 2020;101(11):747-756.
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Audureau E, Carrat F, Layese R, Cagnot C, Asselah T, Guyader D, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Chazouillères O, Mallat A, Grangé J-D, Attali P, d'Alteroche L, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Zucman D, Di Martino V, Sutton A, Pol S, Nahon P. Personalized surveillance for hepatocellular carcinoma in cirrhosis - using machine learning adapted to HCV status. J Hepatol. 2020;73(6):1434-1445.
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Mahévas M, Tran V-T, Roumier M, Chabrol A, Paule R, Guillaud C, Fois E, Lepeule R, Szwebel T-A, Lescure F-X, Schlemmer F, Matignon M, Khellaf M, Crickx E, Terrier B, Morbieu C, Legendre P, Dang J, Schoindre Y, Pawlotsky J-M, Michel M, Perrodeau E, Carlier N, Roche N, de Lastours V, Ourghanlian C, Kerneis S, Ménager P, Mouthon L, Audureau E, Ravaud P, Godeau B, Gallien S, Costedoat-Chalumeau N. Clinical efficacy of hydroxychloroquine in patients with covid-19 pneumonia who require oxygen: observational comparative study using routine care data. BMJ. 2020;369:m1844.
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Rwabihama J-P, Belmin J, Rakotoarisoa DRozier, Hagege M, Audureau E, Benzengli H, Ambime G, Rabus M-T, Bastuji-Garin S, Paillaud E, Oubaya N. Promoting patients' rights at the end of life in a geriatric setting in France: The healthcare professionals' level of knowledge about surrogate decision-makers and advance directives. Patient Educ Couns. 2020;103(7):1390-1398.
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Raffetin A, Melica G, Audureau E, Habibi A, Decousser JW, Fourati S, Razazi K, Lepeule R, Guillaud C, Khellaf M, Bartolucci P, Gallien S. Molecular testing for respiratory pathogens in sickle cell disease adult patients presenting with febrile acute chest syndrome. Med Mal Infect. 2020;50(1):49-56.
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Caeymaex L, Lebeaux C, Roze JChristophe, Danan C, Reynaud A, Jung C, Audureau E. Study on preventing adverse events in neonates (SEPREVEN): A stepped-wedge randomised controlled trial to reduce adverse event rates in the NICU. Medicine (Baltimore). 2020;99(31):e20912.
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Sifaoui I, Oliver L, Tacher V, Fiore A, Lepeule R, Moussafeur A, Huguet R, Teiger E, Audureau E, Derbel H, Luciani A, Kobeiter H, Lim P, Ternacle J, Deux J-F. Diagnostic Performance of Transesophageal Echocardiography and Cardiac Computed Tomography in Infective Endocarditis. J Am Soc Echocardiogr. 2020;33(12):1442-1453.
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Hue S, Beldi-Ferchiou A, Bendib I, Surenaud M, Fourati S, Frapard T, Rivoal S, Razazi K, Carteaux G, Delfau-Larue M-H, Mekontso-Dessap A, Audureau E, de Prost N. Uncontrolled Innate and Impaired Adaptive Immune Responses in Patients with COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020;202(11):1509-1519.
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Bataille P, Amiot A, Claudepierre P, Paris N, Neuraz A, Lerner I, Garcelon N, Rance B, Grisel O, Moreau T, Bernaux M, Audureau E, Sbidian E. Letter: severe COVID-19 infection and biologic therapies-a cohort study of 7 808 patients in France. Aliment Pharmacol Ther. 2020;52(7):1245-1248.
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Badrawy MEl, Nofal A, Saba J, Audureau E. A cohort study of medication adherence among patients with chronic obstructive pulmonary disease in Egypt. NPJ Prim Care Respir Med. 2020;30(1):31.
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Zarski J-P, David-Tchouda S, Trocme C, Margier J, Vilotitch A, Hilleret M-N, Cagnot C, Boursier V, Ziol M, Sutton A, Layese R, Audureau E, Roudot-Thoraval F, Nahon P. Non-invasive fibrosis tests to predict complications in compensated post-hepatitis C cirrhosis. Clin Res Hepatol Gastroenterol. 2020;44(4):524-531.
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Heidet M, Da Cunha T, Brami E, Mermet É, Dru M, Simonnard B, Lecarpentier E, Chollet-Xémard C, Bergeron C, Khalid M, Grunau B, Marty J, Audureau E. EMS Access Constraints And Response Time Delays For Deprived Critically Ill Patients Near Paris, France. Health Aff (Millwood). 2020;39(7):1175-1184.
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Roumenina LT, Chadebech P, Bodivit G, Vieira-Martins P, Grunenwald A, Boudhabhay I, Poillerat V, Pakdaman S, Kiger L, Jouard A, Audureau E, Pirenne F, Galactéros F, Frémeaux-Bacchi V, Bartolucci P. Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy. Am J Hematol. 2020;95(5):456-464.
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Hebert N, Rakotoson MGeorgine, Bodivit G, Audureau E, Bencheikh L, Kiger L, Oubaya N, Pakdaman S, Sakka M, Di Liberto G, Chadebech P, Vingert B, Pirenne F, Galactéros F, Cambot M, Bartolucci P. Individual red blood cell fetal hemoglobin quantification allows to determine protective thresholds in sickle cell disease. Am J Hematol. 2020;95(11):1235-1245.
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Laurent M, Oubaya N, David J-P, Engels C, Canoui-Poitrine F, Corsin L, Liuu E, Audureau E, Bastuji-Garin S, Paillaud E. Functional decline in geriatric rehabilitation ward; is it ascribable to hospital acquired infection? A prospective cohort study. BMC Geriatr. 2020;20(1):433.
2019
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Allaire M, Rekik S, Layese R, Mumana A, Guyot E, Nkontchou G, Bourcier V, Grando V, Ziol M, Nahon P, Ganne-Carrié N, Sutter O, Audureau E, Seror O, Nault J-C. Virologic control and severity of liver disease determine survival after radiofrequency ablation of hepatocellular carcinoma on cirrhosis. Dig Liver Dis. 2019;51(1):86-94.
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Audureau E, Besson MHélène, Nofal A, Jayasundera R, Saba J, Ladner J. Ability to pay for medication: a clustering analysis of 1404 patients with the Patient Financial Eligibility Tool. J Comp Eff Res. 2019;8(12):969-977.
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Hurtaud A, Aubin M, Ferrat E, Lebreton J, Paillaud E, Audureau E, Bastuji-Garin S, Chouaid C, Boisnault P, Clerc P, Canoui-Poitrine F. Continuity of care in general practice at cancer diagnosis (COOC-GP study): a national cohort study of 2853 patients. Br J Gen Pract. 2019;69(679):e88-e96.
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Ahmed-Yahia S, Decousser J-W, Flouzat-Lachaniette CHenri, Dervin G, Roubineau F, Audureau E, Hourdille A, Royer G, Eymard F, Chevalier X. Is the discopathy associated with Modic changes an infectious process? Results from a prospective monocenter study. PLoS One. 2019;14(8):e0221030.
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Costentin CE, Layese R, Roudot-Thoraval F, Audureau E, Nahon P. Reply. Gastroenterology. 2019;156(1):289-290.
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Bassez G, Audureau E, Peschanski M. Reply: Could weight loss contribute to the improved mobility with metformin in patients with myotonic dystrophy type 1?. Brain. 2019;142(2):e6.
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Blondiaux E, Autret G, Dhombres F, Gonzales M, Audureau E, Clément O, Jouannic J-M, Houyel L. Evaluation of septal insertion of atrioventricular valves in fetuses by postmortem 4.7 Tesla cardiac MRI: A feasibility study. Diagn Interv Imaging. 2019;100(2):109-116.
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Salmon-Céron D, Nahon P, Layese R, Bourcier V, Sogni P, Bani-Sadr F, Audureau E, Merchadou L, Dabis F, Wittkop L, Roudot-Thoraval F. Human Immunodeficiency Virus/Hepatitis C Virus (HCV) Co-infected Patients With Cirrhosis Are No Longer at Higher Risk for Hepatocellular Carcinoma or End-Stage Liver Disease as Compared to HCV Mono-infected Patients. Hepatology. 2019;70(3):939-954.
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Attias P, Melica G, Boutboul D, De Castro N, Audard V, Stehlé T, Gaube G, Fourati S, Botterel F, Fihman V, Audureau E, Grimbert P, Matignon M. Epidemiology, Risk Factors, and Outcomes of Opportunistic Infections after Kidney Allograft Transplantation in the Era of Modern Immunosuppression: A Monocentric Cohort Study. J Clin Med. 2019;8(5).
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Thabut D, Bureau C, Layese R, Bourcier V, Hammouche M, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Goria O, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle-Bladou C, Dao T, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Hillaire S, Di Martino V, Sutton A, Audureau E, Roudot-Thoraval F, Nahon P. Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy. Gastroenterology. 2019;156(4):997-1009.e5.
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Valembois L, Audureau E, Takeda A, Jarzebowski W, Belmin J, Lafuente-Lafuente C. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst RevCochrane Database Syst RevCochrane Database Syst Rev. 2019;9:Cd005049.
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Gracies J-M, Pradines M, Ghédira M, Loche C-M, Mardale V, Hennegrave C, Gault-Colas C, Audureau E, Hutin E, Baude M, Bayle N. Guided Self-rehabilitation Contract vs conventional therapy in chronic stroke-induced hemiparesis: NEURORESTORE, a multicenter randomized controlled trial. BMC Neurol. 2019;19(1):39.
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Brichler S, Nahon P, Zoulim F, Layese R, Bourcier V, Audureau E, Sutton A, Letouze E, Cagnot C, Marcellin P, Guyader D, Roulot D, Pol S, De Lédinghen V, Zarski J-P, Calès P, Tran A, Péron J-M, Mallat A, Riachi G, Grangé J-D, Blanc J-F, Bacq Y, Ouzan D, Bronowicki J-P, Mathurin P, Larrey D, Alric L, Attali P, Serfaty L, Pilette C, Bourlière M, Thabut D, Silvain C, Wartelle C, Zucman D, Christidis C, Roudot-Thoraval F, Ganne-Carrié N. Non-virological factors are drivers of hepatocellular carcinoma in virosuppressed hepatitis B cirrhosis: Results of ANRS CO12 CirVir cohort. J Viral Hepat. 2019;26(3):384-396.
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Lalevée S, Audureau E, Riou A, Colin A, Anquetin M, Barau C, Valeyrie-Allanore L, Delfau-Larue M-H, Chosidow O, Wolkenstein P, Ingen-Housz-Oro S, Hue S. Acute generalized exanthematous pustulosis and epidermal necrolysis differ in innate cytokine patterns. Clin Exp Allergy. 2019;49(9):1258-1261.
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Contou D, Canoui-Poitrine F, Coudroy R, Préau S, Cour M, Barbier F, Terzi N, Schnell G, Galbois A, Zafrani L, Zuber B, Ehrmann S, Gelisse E, Colling D, Schmidt M, Jaber S, Conia A, Sonneville R, Colin G, Guérin L, Roux D, Jochmans S, Kentish-Barnes N, Audureau E, Layese R, Alves A, Ouedraogo R, Brun-Buisson C, Dessap AMekontso, de Prost N. Long-term Quality of Life in Adult Patients Surviving Purpura Fulminans: An Exposed-Unexposed Multicenter Cohort Study. Clin Infect Dis. 2019;69(2):332-340.
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Clause-Verdreau A-C, Audureau E, Leplège A, Coste J. Contrasted trends in health-related quality of life across gender, age categories and work status in France, 1995-2016: repeated population-based cross-sectional surveys using the SF-36. J Epidemiol Community Health. 2019;73(1):65-72.
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Valembois L, Audureau E, Takeda A, Jarzebowski W, Belmin J, Lafuente-Lafuente C. Antiarrhythmics for maintaining sinus rhythm after cardioversion of atrial fibrillation. Cochrane Database Syst RevCochrane Database Syst RevCochrane Database Syst Rev. 2019;9:CD005049.
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Baghdoyan S, Bassez G, Audureau E, Peschanski M. [Pharmacological research and pluripotent stem cells: from the innovative experimental paradigm to the successful clinical trial]. Med Sci (Paris). 2019;35(1):26-29.
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Segaux L, Oubaya N, Broussier A, Baude M, Canoui-Poitrine F, Naga H, Laurent M, Leissing-Desprez C, Audureau E, Ferrat E, Chailloleau C, Fromantin I, David J-P, Bastuji-Garin S. Identification of five frailty profiles in community-dwelling individuals aged 50-75: A latent class analysis of the SUCCEED survey data. Maturitas. 2019;127:1-11.
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Audureau E, Davis B, Besson MHélène, Saba J, Ladner J. Willingness to pay for medical treatments in chronic diseases: a multicountry survey of patients and physicians. J Comp Eff Res. 2019;8(5):357-369.
2018
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Bassez G, Audureau E, Hogrel J-Y, Arrouasse R, Baghdoyan S, Bhugaloo H, Gourlay-Chu M-L, Le Corvoisier P, Peschanski M. Improved mobility with metformin in patients with myotonic dystrophy type 1: a randomized controlled trial. Brain. 2018;141(10):2855-2865.
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Villafane G, Thiriez C, Audureau E, Straczek C, Kerschen P, Cormier-Dequaire F, Van Der Gucht A, Gurruchaga J-M, Quéré-Carne M, Evangelista E, Paul M, Defer G, Damier P, Remy P, Itti E, Fénelon G. High-dose transdermal nicotine in Parkinson's disease patients: a randomized, open-label, blinded-endpoint evaluation phase 2 study. Eur J Neurol. 2018;25(1):120-127.
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Heidet M, Mermet É, Vaux J, Jérémie R, Audureau E, Marty J. Simulated EMS response times until patients located in public train stations: A geospatial model to improve on-foot accessibility. Resuscitation. 2018;131:e3-e5.
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Ridouani F, Damy T, Tacher V, Derbel H, Legou F, Sifaoui I, Audureau E, Bodez D, Rahmouni A, Deux J-F. Myocardial native T2 measurement to differentiate light-chain and transthyretin cardiac amyloidosis and assess prognosis. J Cardiovasc Magn Reson. 2018;20(1):58.
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Costentin CE, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Zucman D, Di Martino V, Sutton A, Letouze E, Imbeaud S, Zucman-Rossi J, Audureau E, Roudot-Thoraval F, Nahon P. Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study. Gastroenterology. 2018;155(2):431-442.e10.
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Winter A, Féray C, Audureau E, Azoulay D, Antoine C, Daurès J-P, Landais P. Author Correction: A Donor Quality Index for liver transplantation: development, internal and external validation. Sci Rep. 2018;8(1):15109.
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Winter A, Féray C, Audureau E, Azoulay D, Antoine C, Daurès J-P, Landais P. A Donor Quality Index for liver transplantation: development, internal and external validation. Sci Rep. 2018;8(1):9871.
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Bastard J-P, Fellahi S, Audureau E, Layese R, Roudot-Thoraval F, Cagnot C, Mahuas-Bourcier V, Sutton A, Ziol M, Capeau J, Nahon P. Elevated adiponectin and sTNFRII serum levels can predict progression to hepatocellular carcinoma in patients with compensated HCV1 cirrhosis. Eur Cytokine Netw. 2018;29(3):112-120.
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Rwabihama J-P, Audureau E, Laurent M, Rakotoarisoa L, Jegou M, Saddedine S, Krypciak S, Herbaud S, Benzengli H, Segaux L, Guery E, Ambime G, Rabus M-T, Perilliat J-G, David J-P, Paillaud E. Prophylaxis of Venous Thromboembolism in Geriatric Settings: A Cluster-Randomized Multicomponent Interventional Trial. J Am Med Dir Assoc. 2018;19(6):497-503.
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Boyer L, Bastuji-Garin S, Chouaid C, Housset B, Le Corvoisier P, Derumeaux G, Boczkowski J, Maitre B, Adnot S, Audureau E. Are Systemic Manifestations Ascribable to COPD in Smokers? A Structural Equation Modeling Approach. Sci Rep. 2018;8(1):8569.
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Audureau E, Guellich A, Guery E, Canoui-Poitrine F, Benedyga V, Duchossoir H, Taieb C, Damy T. Development and Validation of a New Tool to Assess Burden of Dietary Sodium Restriction in Patients with Chronic Heart Failure: The BIRD Questionnaire. Nutrients. 2018;10(10).
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Audureau E, Simon-Deckers A, Franco-Montoya M-L, Annangi B, Kermanizadeh A, Boczkowski J, Lanone S. Substantial modification of the gene expression profile following exposure of macrophages to welding-related nanoparticles. Sci Rep. 2018;8(1):8554.
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Gellen B, Messonnier LA, Galactéros F, Audureau E, Merlet AN, Rupp T, Peyrot S, Martin C, Féasson L, Bartolucci P. Moderate-intensity endurance-exercise training in patients with sickle-cell disease without severe chronic complications (EXDRE): an open-label randomised controlled trial. Lancet Haematol. 2018;5(11):e554-e562.
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Bocahut N, Audureau E, Poignard A, Delambre J, Queinnec S, Lachaniette C-HFlouzat, Allain J. Incidence and impact of implant subsidence after stand-alone lateral lumbar interbody fusion. Orthop Traumatol Surg Res. 2018;104(3):405-410.
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Laurent M, Guetz GDes, Bastuji-Garin S, Culine S, Caillet P, Aparicio T, Audureau E, Carvahlo-Verlinde M, Reinald N, Tournigand C, Landre T, LeThuaut A, Paillaud E, Canoui-Poitrine F. Chronological Age and Risk of Chemotherapy Nonfeasibility: A Real-Life Cohort Study of 153 Stage II or III Colorectal Cancer Patients Given Adjuvant-modified FOLFOX6. Am J Clin Oncol. 2018;41(1):73-80.
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Ferrat E, Bastuji-Garin S, Paillaud E, Caillet P, Clerc P, Moscova L, Gouja A, Renard V, Attali C, Le Breton J, Audureau E. Efficacy of nurse-led and general practitioner-led comprehensive geriatric assessment in primary care: protocol of a pragmatic three-arm cluster randomised controlled trial (CEpiA study). BMJ Open. 2018;8(4):e020597.
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Le Corvoisier P, Gallet R, Lesault P-F, Audureau E, Paul M, Ternacle J, Ghostine S, Champagne S, Arrouasse R, Bitari D, Mouillet G, Dubois-Randé J-L, Berdeaux A, Ghaleh B, Deux J-F, Teiger E. Intra-coronary morphine versus placebo in the treatment of acute ST-segment elevation myocardial infarction: the MIAMI randomized controlled trial. BMC Cardiovasc Disord. 2018;18(1):193.
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Cacoub P, Nahon P, Layese R, Blaise L, Desbois AClaire, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Capron D, Thiefin G, Zucman D, Di Martino V, Bagnis CIsnard, Ziol M, Sutton A, Letouze E, Roudot-Thoraval F, Audureau E. Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients. Am Heart J. 2018;198:4-17.
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Blondiaux E, Chougar L, Gelot A, Valence S, Audureau E, le Pointe HDucou, Jouannic J-M, Dhombres F, Garel C. Developmental patterns of fetal fat and corresponding signal on T1-weighted magnetic resonance imaging. Pediatr Radiol. 2018;48(3):317-324.
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Audureau E, Roux F, D Danic L, Bagot M, Cantagrel A, Dernis E, Gouyette N, Hilliquin P, Jullien D, Lioté F, Passeron T, Richard MA, Claudepierre P. Psoriatic arthritis screening by the dermatologist: development and first validation of the 'PURE-4 scale'. J Eur Acad Dermatol Venereol. 2018;32(11):1950-1953.
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Schlemmer F, Boyer L, Soumagne T, Ridoux A, Chouaid C, Maitre B, Lanone S, Adnot S, Audureau E, Boczkowski J. Beclin1 circulating levels and accelerated aging markers in COPD. Cell Death Dis. 2018;9(2):156.
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Allaire M, Nahon P, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Zucman D, Di Martino V, Sutton A, Letouze E, Audureau E, Roudot-Thoraval F. Extrahepatic cancers are the leading cause of death in patients achieving hepatitis B virus control or hepatitis C virus eradication. Hepatology. 2018;68(4):1245-1259.
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Audureau E, Chivet A, Ursu R, Corns R, Metellus P, Noel G, Zouaoui S, Guyotat J, Le Reste P-J, Faillot T, Litre F, Desse N, Petit A, Emery E, Lechapt-Zalcman E, Peltier J, Duntze J, Dezamis E, Voirin J, Menei P, Caire F, Hieu PDam, Barat J-L, Langlois O, Vignes J-R, Fabbro-Peray P, Riondel A, Sorbets E, Zanello M, Roux A, Carpentier A, Bauchet L, Pallud J. Prognostic factors for survival in adult patients with recurrent glioblastoma: a decision-tree-based model. J Neurooncol. 2018;136(3):565-576.
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Nahon P, Layese R, Bourcier V, Cagnot C, Marcellin P, Guyader D, Pol S, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Thabut D, Pilette C, Silvain C, Christidis C, Nguyen-Khac E, Bernard-Chabert B, Zucman D, Di Martino V, Sutton A, Roudot-Thoraval F, Audureau E. Incidence of Hepatocellular Carcinoma After Direct Antiviral Therapy for HCV in Patients With Cirrhosis Included in Surveillance Programs. Gastroenterology. 2018;155(5):1436-1450.e6.
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Heidet M, Amathieu R, Audureau E, Augusto O, de Barmon VNicolazo, Rialland A, Schmitz D, Pierrang F, Marty J, Chollet-Xémard C, Thirion O, Jacob L. Efficacy and tolerance of early administration of tranexamic acid in patients with cirrhosis presenting with acute upper gastrointestinal bleeding: a study protocol for a multicentre, randomised, double-blind, placebo-controlled trial (the EXARHOSE study). BMJ Open. 2018;8(8):e021943.
2017
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Audureau E, Hua C, de Prost N, Hemery F, Decousser JW, Bosc R, Lepeule R, Chosidow O, Sbidian E. Mortality of necrotizing fasciitis: relative influence of individual and hospital-level factors, a nationwide multilevel study, France, 2007-12. Br J Dermatol. 2017;177(6):1575-1582.
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Azoulay D, Audureau E, Bhangui P, Belghiti J, Boillot O, Andreani P, Castaing D, Cherqui D, Irtan S, Calmus Y, Chazouillères O, Soubrane O, Luciani A, Féray C. Living or Brain-dead Donor Liver Transplantation for Hepatocellular Carcinoma: A Multicenter, Western, Intent-to-treat Cohort Study. Ann Surg. 2017;266(6):1035-1044.
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Winter A, Féray C, Audureau E, Écochard R, Jacquelinet C, Roudot-Thoraval F, Duvoux C, Daurès J-P, Landais P. External validation of the Donor Risk Index and the Eurotransplant Donor Risk Index on the French liver transplantation registry. Liver Int. 2017;37(8):1229-1238.
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Ternacle J, Wan F, Sawaki D, Surenaud M, Pini M, Mercedes R, Ernande L, Audureau E, Dubois-Randé J-L, Adnot S, Hue S, Czibik G, Derumeaux G. Short-term high-fat diet compromises myocardial function: a radial strain rate imaging study. Eur Heart J Cardiovasc Imaging. 2017;18(11):1283-1291.
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Soreze Y, Audureau E, Decobert F, Jaby O, Blary S, Danan C, Durrmeyer X. Reduced Sufentanil Doses are Effective for Postoperative Analgesia After Ductal Closure in Extremely Premature Infants: A 10 Years Retrospective Cohort Study. Clin J Pain. 2017;33(12):1109-1116.
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Pamoukdjian F, Canoui-Poitrine F, Longelin-Lombard C, Aparicio T, Ganne N, Wind P, Martinez-Tapia C, Audureau E, Sebbane G, Zelek L, Paillaud E. Diagnostic performance of gait speed, G8 and G8 modified indices to screen for vulnerability in older cancer patients: the prospective PF-EC cohort study. Oncotarget. 2017;8(31):50393-50402.
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Notarpaolo A, Layese R, Magistri P, Gambato M, Colledan M, Magini G, Miglioresi L, Vitale A, Vennarecci G, Ambrosio CD, Burra P, Di Benedetto F, Fagiuoli S, Colasanti M, Ettorre GMaria, Andreoli A, Cillo U, Laurent A, Katsahian S, Audureau E, Roudot-Thoraval F, Duvoux C. Validation of the AFP model as a predictor of HCC recurrence in patients with viral hepatitis-related cirrhosis who had received a liver transplant for HCC. J Hepatol. 2017;66(3):552-559.
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Nahon P, Bourcier V, Layese R, Audureau E, Cagnot C, Marcellin P, Guyader D, Fontaine H, Larrey D, De Lédinghen V, Ouzan D, Zoulim F, Roulot D, Tran A, Bronowicki J-P, Zarski J-P, Leroy V, Riachi G, Calès P, Péron J-M, Alric L, Bourlière M, Mathurin P, Dharancy S, Blanc J-F, Abergel A, Serfaty L, Mallat A, Grangé J-D, Attali P, Bacq Y, Wartelle C, Dao T, Benhamou Y, Pilette C, Silvain C, Christidis C, Capron D, Bernard-Chabert B, Zucman D, Di Martino V, Thibaut V, Salmon D, Ziol M, Sutton A, Pol S, Roudot-Thoraval F. Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications. Gastroenterology. 2017;152(1):142-156.e2.
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Martinez-Tapia C, Paillaud E, Liuu E, Tournigand C, Ibrahim R, Fossey-Diaz V, Culine S, Canoui-Poitrine F, Audureau E. Prognostic value of the G8 and modified-G8 screening tools for multidimensional health problems in older patients with cancer. Eur J Cancer. 2017;83:211-219.
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Ladner J, Rodrigues M, Davis B, Besson M-H, Audureau E, Saba J. Societal impact of dengue outbreaks: Stakeholder perceptions and related implications. A qualitative study in Brazil, 2015. PLoS Negl Trop Dis. 2017;11(3):e0005366.
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Ladner J, Davis B, Audureau E, Saba J. Treatment-seeking patterns for malaria in pharmacies in five sub-Saharan African countries. Malar J. 2017;16(1):353.
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Jourjon R, Morel B, Irtan S, Audureau E, Coulomb-L'Herminé A, Larroquet M, le Pointe HDucou, Blondiaux E. Analysis of Clinical and Ultrasound Determinants of Adnexal Torsion in Children and Adolescents. J Pediatr Adolesc Gynecol. 2017;30(5):582-590.
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Ferrat E, Paillaud E, Caillet P, Laurent M, Tournigand C, Lagrange J-L, Droz J-P, Balducci L, Audureau E, Canoui-Poitrine F, Bastuji-Garin S. Performance of Four Frailty Classifications in Older Patients With Cancer: Prospective Elderly Cancer Patients Cohort Study. J Clin Oncol. 2017;35(7):766-777.
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Ernande L, Audureau E, Jellis CL, Bergerot C, Henegar C, Sawaki D, Czibik G, Volpi C, Canoui-Poitrine F, Thibault H, Ternacle J, Moulin P, Marwick TH, Derumeaux G. Clinical Implications of Echocardiographic Phenotypes of Patients With Diabetes Mellitus. J Am Coll Cardiol. 2017;70(14):1704-1716.
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Deux J-F, Audard V, Brugières P, Habibi A, Manea E-M, Guillaud-Danis C, Godeau B, Galactéros F, Stehlé T, Lang P, Grimbert P, Audureau E, Rahmouni A, Bartolucci P. Magnetic Resonance Imaging Assessment of Kidney Oxygenation and Perfusion During Sickle Cell Vaso-occlusive Crises. Am J Kidney Dis. 2017;69(1):51-59.
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Blondiaux E, Pidial L, Autret G, Rahmi G, Balvay D, Audureau E, Wilhelm C, Guerin CL, Bruneval P, Silvestre J-S, Menasché P, Clément O. Bone marrow-derived mesenchymal stem cell-loaded fibrin patches act as a reservoir of paracrine factors in chronic myocardial infarction. J Tissue Eng Regen Med. 2017;11(12):3417-3427.
2016
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Yiou R, Bütow Z, Parisot J, Lingombet O, Augustin D, de la Taille A, Salomon L, Audureau E. Update on 2-year outcomes of the TOMS™ transobturator male sling for the treatment of male stress urinary incontinence. Neurourol Urodyn. 2016;35(1):44-7.
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Audureau E, Pouchot J, Coste J. Gender-Related Differential Effects of Obesity on Health-Related Quality of Life via Obesity-Related Comorbidities: A Mediation Analysis of a French Nationwide Survey. Circ Cardiovasc Qual Outcomes. 2016;9(3):246-56.
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Ternacle J, Bodez D, Guellich A, Audureau E, Rappeneau S, Lim P, Radu C, Guendouz S, Couetil J-P, Benhaiem N, Hittinger L, Dubois-Randé J-L, Planté-Bordeneuve V, Mohty D, Deux J-F, Damy T. Causes and Consequences of Longitudinal LV Dysfunction Assessed by 2D Strain Echocardiography in Cardiac Amyloidosis. JACC Cardiovasc Imaging. 2016;9(2):126-38.
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Schneck A-S, Lazzati A, Audureau E, Hemery F, Gugenheim J, Azoulay D, Iannelli A. One or two steps for laparoscopic conversion of failed adjustable gastric banding to sleeve gastrectomy: a nationwide French study on 3357 morbidly obese patients. Surg Obes Relat Dis. 2016;12(4):840-848.
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Martinez-Tapia C, Canoui-Poitrine F, Bastuji-Garin S, Soubeyran P, Mathoulin-Pelissier S, Tournigand C, Paillaud E, Laurent M, Audureau E. Optimizing the G8 Screening Tool for Older Patients With Cancer: Diagnostic Performance and Validation of a Six-Item Version. Oncologist. 2016;21(2):188-95.
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Lim C, Audureau E, Salloum C, Levesque E, Lahat E, Merle JClaude, Compagnon P, Dhonneur G, Féray C, Azoulay D. Acute kidney injury following hepatectomy for hepatocellular carcinoma: incidence, risk factors and prognostic value. HPB (Oxford). 2016;18(6):540-8.
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Lazzati A, Audureau E, Hemery F, Schneck A-S, Gugenheim J, Azoulay D, Iannelli A. Reduction in early mortality outcomes after bariatric surgery in France between 2007 and 2012: A nationwide study of 133,000 obese patients. Surgery. 2016;159(2):467-74.
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Ladner J, Besson M-H, Audureau E, Rodrigues M, Saba J. Experiences and lessons learned from 29 HPV vaccination programs implemented in 19 low and middle-income countries, 2009-2014. BMC Health Serv Res. 2016;16(1):575.
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Hélage S, Revel MP, Chabi ML, Audureau E, Ferretti G, Laurent F, Alifano M, Mansuet-Lupo A, Buy JN, Vadrot D. Solitary fibrous tumor of the pleura: Can computed tomography features help predict malignancy? A series of 56 patients with histopathological correlates. Diagn Interv Imaging. 2016;97(3):347-53.
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Galat A, Guellich A, Bodez D, Slama M, Dijos M, Zeitoun DMessika, Milleron O, Attias D, Dubois-Randé J-L, Mohty D, Audureau E, Teiger E, Rosso J, Monin J-L, Damy T. Aortic stenosis and transthyretin cardiac amyloidosis: the chicken or the egg?. Eur Heart J. 2016;37(47):3525-3531.
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Ferrat E, Le Breton J, Guéry E, Adeline F, Audureau E, Montagne O, Roudot-Thoraval F, Attali C, Le Corvoisier P, Renard V. Effects 4.5 years after an interactive GP educational seminar on antibiotic therapy for respiratory tract infections: a randomized controlled trial. Fam Pract. 2016;33(2):192-9.
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Ferrat E, Audureau E, Paillaud E, Liuu E, Tournigand C, Lagrange J-L, Canoui-Poitrine F, Caillet P, Bastuji-Garin S. Four Distinct Health Profiles in Older Patients With Cancer: Latent Class Analysis of the Prospective ELCAPA Cohort. J Gerontol A Biol Sci Med Sci. 2016;71(12):1653-1660.
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Chaput U, Vienne A, Audureau E, Bauret P, Bichard P, Coumaros D, Napoléon B, Ponchon T, Duchmann J-C, Laugier R, Lamouliatte H, Védrenne B, Gaudric M, Chaussade S, Robin F, Leblanc S, Prat F. Temporary placement of fully covered self-expandable metal stents for the treatment of benign biliary strictures. United European Gastroenterol J. 2016;4(3):403-12.
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Boyer L, Audureau E, Margarit L, Marcos E, Bizard E, Le Corvoisier P, Macquin-Mavier I, Derumeaux G, Damy T, Drouot X, Covali-Noroc A, Boczkowski J, Bastuji-Garin S, Adnot S. Telomere Shortening in Middle-Aged Men with Sleep-disordered Breathing. Ann Am Thorac Soc. 2016;13(7):1136-43.
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Blondiaux E, Laurent M, Audureau E, Boudjemaa S, Sileo C, Lenoir M, Dainese L, Garel C, Coulomb A, le Pointe HDucou. Factors influencing the diagnostic yield and accuracy of image-guided percutaneous needle biopsy of pediatric tumors: single-center audit of a 26-year experience. Pediatr Radiol. 2016;46(3):372-82.
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Blondiaux J, Naji S, Audureau E, Colard T. Cementochronology and sex: A reappraisal of sex-associated differences in survival in past French societies. Int J Paleopathol. 2016;15:152-163.
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Bartolucci P, Habibi A, Stehlé T, Di Liberto G, Rakotoson MGeorgine, Gellen-Dautremer J, Loric S, Moutereau S, Sahali D, Wagner-Ballon O, Remy P, Lang P, Grimbert P, Audureau E, Godeau B, Galactéros F, Audard V. Six Months of Hydroxyurea Reduces Albuminuria in Patients with Sickle Cell Disease. J Am Soc Nephrol. 2016;27(6):1847-53.
2015
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Yiou R, Loche C-M, Lingombet O, Abbou C, Salomon L, de la Taille A, Audureau E. Evaluation of urinary symptoms in patients with post-prostatectomy urinary incontinence treated with the male sling TOMS. Neurourol Urodyn. 2015;34(1):12-7.
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Yiou R, Bütow Z, Parisot J, Binhas M, Lingombet O, Augustin D, de la Taille A, Audureau E. Is it worth continuing sexual rehabilitation after radical prostatectomy with intracavernous injection of alprostadil for more than 1 year?. Sex Med. 2015;3(1):42-8.
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Yiou R, Bütow Z, Baron T, Salomon L, Audureau E. Adjustable continence therapy (ProACT™) after male sling failure for patients with post-radical prostatectomy urinary incontinence: a prospective study with one-year follow-up. World J Urol. 2015;33(9):1331-6.
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Yiou R, Audureau E, Loche C-M, Dussaud M, Lingombet O, Binhas M. Comprehensive evaluation of embarrassment and pain associated with invasive urodynamics. Neurourol Urodyn. 2015;34(2):156-60.
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Revel M-P, Fitton I, Audureau E, Benzakoun J, Lederlin M, Chabi M-L, Rousset P. Breast dose reduction options during thoracic CT: influence of breast thickness. AJR Am J Roentgenol. 2015;204(4):W421-8.
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Rakotoson MGeorgine, Di Liberto G, Audureau E, Habibi A, Fauroux C, Khorgami S, Hulin A, Loric S, Noizat-Pirenne F, Galactéros F, Bartolucci P. Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea. Orphanet J Rare Dis. 2015;10:57.
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Pallud J, Audureau E, Noel G, Corns R, Lechapt-Zalcman E, Duntze J, Pavlov V, Guyotat J, Hieu PDam, Le Reste P-J, Faillot T, Litre C-F, Desse N, Petit A, Emery E, Voirin J, Peltier J, Caire F, Vignes J-R, Barat J-L, Langlois O, Dezamis E, Parraga E, Zanello M, Nader E, Lefranc M, Bauchet L, Devaux B, Menei P, Metellus P. Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort. Neuro Oncol. 2015;17(12):1609-19.
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Laurent M, Bastuji-Garin S, Plonquet A, Bories PN, Le Thuaut A, Audureau E, Lang PO, Nakib S, Liuu E, Canoui-Poitrine F, Paillaud E. Interrelations of immunological parameters, nutrition, and healthcare-associated infections: prospective study in elderly in-patients. Clin Nutr. 2015;34(1):79-85.
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Launay N, Silvera S, Tenenbaum F, Groussin L, Tissier F, Audureau E, Vignaux O, Dousset B, Bertagna X, Legmann P. Value of 18-F-FDG PET/CT and CT in the Diagnosis of Indeterminate Adrenal Masses. Int J Endocrinol. 2015;2015:213875.
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Ladner J, Besson M-H, Rodrigues M, Saba J, Audureau E. Performance of HIV Prevention of Mother-To-Child Transmission Programs in Sub-Saharan Africa: Longitudinal Assessment of 64 Nevirapine-Based Programs Implemented in 25 Countries, 2000-2011. PLoS One. 2015;10(6):e0130103.
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Esteban H, Blondiaux E, Audureau E, Sileo C, Moutard ML, Gelot A, Jouannic JM, H le Pointe D, Garel C. Prenatal features of isolated subependymal pseudocysts associated with adverse pregnancy outcome. Ultrasound Obstet Gynecol. 2015;46(6):678-87.
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Coolen N, Morand P, Martin C, Hubert D, Kanaan R, Chapron J, Honoré I, Dusser D, Audureau E, Veziris N, Burgel P-R. Reduced risk of nontuberculous mycobacteria in cystic fibrosis adults receiving long-term azithromycin. J Cyst Fibros. 2015;14(5):594-9.
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Boyer L, Chouaid C, Bastuji-Garin S, Marcos E, Margarit L, Le Corvoisier P, Vervoitte L, Hamidou L, Frih L, Audureau E, Covali-Noroc A, Andujar P, Saakashvili Z, Lino A, Ghaleh B, Hue S, Derumeaux G, Housset B, Dubois-Randé J-L, Boczkowski J, Maitre B, Adnot S. Aging-related systemic manifestations in COPD patients and cigarette smokers. PLoS One. 2015;10(3):e0121539.
2014
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Parisot J, Yiou R, Salomon L, de la Taille A, Lingombet O, Audureau E. Erection hardness score for the evaluation of erectile dysfunction: further psychometric assessment in patients treated by intracavernous prostaglandins injections after radical prostatectomy. J Sex Med. 2014;11(8):2109-18.
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Pallud J, Audureau E, Blonski M, Sanai N, Bauchet L, Fontaine D, Mandonnet E, Dezamis E, Psimaras D, Guyotat J, Peruzzi P, Page P, Gal B, Parraga E, Baron M-H, Vlaicu M, Guillevin R, Devaux B, Duffau H, Taillandier L, Capelle L, Huberfeld G. Epileptic seizures in diffuse low-grade gliomas in adults. Brain. 2014;137(Pt 2):449-62.
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Mézière A, Audureau E, Vairelles S, Krypciak S, Dicko M, Monié M, Giraudier S. B12 deficiency increases with age in hospitalized patients: a study on 14,904 samples. J Gerontol A Biol Sci Med Sci. 2014;69(12):1576-85.
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Liuu E, Canoui-Poitrine F, Tournigand C, Laurent M, Caillet P, Le Thuaut A, Vincent H, Culine S, Audureau E, Bastuji-Garin S, Paillaud E. Accuracy of the G-8 geriatric-oncology screening tool for identifying vulnerable elderly patients with cancer according to tumour site: the ELCAPA-02 study. J Geriatr Oncol. 2014;5(1):11-9.
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Lecomte F, Huet S, Audureau E, Guyerdet V, Pourriat J-L, Claessens Y-E. Patients in pain that refuse acetaminophen at triage. Am J Emerg Med. 2014;32(4):388-9.
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Ladner J, Besson M-H, Rodrigues M, Audureau E, Saba J. Performance of 21 HPV vaccination programs implemented in low and middle-income countries, 2009-2013. BMC Public Health. 2014;14:670.
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Coste J, Quinquis L, D'Almeida S, Audureau E. Smoking and health-related quality of life in the general population. Independent relationships and large differences according to patterns and quantity of smoking and to gender. PLoS One. 2014;9(3):e91562.
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Bütow Z, Audureau E, Salomon L, De la Taille A, Yiou R. [Not Available]. Prog Urol. 2014;24(13):890.
2013
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Coste J, Quinquis L, Audureau E, Pouchot J. Non response, incomplete and inconsistent responses to self-administered health-related quality of life measures in the general population: patterns, determinants and impact on the validity of estimates - a population-based study in France using the MOS S. Health Qual Life Outcomes. 2013;11:44.
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Chaput U, Heresbach D, Audureau E, Vanbiervliet G, Gaudric M, Bichard P, Bauret P, Coumaros D, Ponchon T, Fumex F, Bensoussan E, Lamouliatte H, Chryssostalis A, Robin F, Prat F. Comparison of a standard fully covered stent with a super-thick silicone-covered stent for the treatment of refractory esophageal benign strictures: A prospective multicenter study. United European Gastroenterol J. 2013;1(2):93-102.
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Blondiaux E, Pidial L, Vilar J, Autret G, Balvay D, Audureau E, Bruneval P, Bel A, Cuenod C-A, Silvestre J-S, Clément O. Evaluation of rat heart microvasculature with high-spatial-resolution susceptibility-weighted MR imaging. Radiology. 2013;269(1):277-82.
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Audureau E, Rican S, Coste J. Worsening trends and increasing disparities in health-related quality of life: evidence from two French population-based cross-sectional surveys, 1995-2003. Qual Life Res. 2013;22(1):13-26.
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Audureau E, Rican S, Coste J. From deindustrialization to individual health-related quality of life: multilevel evidence of contextual predictors, mediators and modulators across French regions, 2003. Health Place. 2013;22:140-52.
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Audureau E, Kahn JG, Besson M-H, Saba J, Ladner J. Scaling up prevention of mother-to-child HIV transmission programs in sub-Saharan African countries: a multilevel assessment of site-, program- and country-level determinants of performance. BMC Public Health. 2013;13:286.
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Tekinturhan E, Audureau E, Tavolacci M-P, Garcia-Gonzalez P, Ladner J, Saba J. Improving access to care in low and middle-income countries: institutional factors related to enrollment and patient outcome in a cancer drug access program. BMC Health Serv Res. 2013;13:304.
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Saba J, Audureau E, Bizé M, Koloshuk B, Ladner J. Development and validation of a multilateral index to determine economic status in developing countries: the Patient Financial Eligibility Tool (PFET). Popul Health Manag. 2013;16(2):82-9.
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Rousset P, Chaillot P-F, Audureau E, Rey-Salmon C, Becour B, Fitton I, Vadrot D, Revel M-P. Detection of residual packets in cocaine body packers: low accuracy of abdominal radiography-a prospective study. Eur Radiol. 2013;23(8):2146-55.
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Pallud J, Blonski M, Mandonnet E, Audureau E, Fontaine D, Sanai N, Bauchet L, Peruzzi P, Frénay M, Colin P, Guillevin R, Bernier V, Baron M-H, Guyotat J, Duffau H, Taillandier L, Capelle L. Velocity of tumor spontaneous expansion predicts long-term outcomes for diffuse low-grade gliomas. Neuro Oncol. 2013;15(5):595-606.
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Ladner J, Tekinturhan E, Tavolacci M-P, Audureau E, Saba J. Increasing access to care for chronic myeloid leukemia patients: assessment of a scaling-up program. J Health Care Poor Underserved. 2013;24(4):1486-97.
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Ladner J, Besson M-H, Rodrigues M, Sams K, Audureau E, Saba J. Prevention of mother-to-child HIV transmission in resource-limited settings: assessment of 99 Viramune Donation Programmes in 34 countries, 2000-2011. BMC Public Health. 2013;13:470.
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Guedj M, Saad A, Audureau E, Gatinel D. Photorefractive keratectomy in patients with suspected keratoconus: five-year follow-up. J Cataract Refract Surg. 2013;39(1):66-73.
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Fauque P, Audureau E, Leandri R, Delaroche L, Assouline S, Epelboin S, Jouannet P, Patrat C. Is the nuclear status of an embryo an independent factor to predict its ability to develop to term?. Fertil Steril. 2013;99(5):1299-1304.e3.
2012
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Ettou S, Audureau E, Humbrecht C, Benet B, Jammes H, Clozel T, Bardet V, Lacombe C, Dreyfus F, Mayeux P, Solary E, Fontenay M. Fas expression at diagnosis as a biomarker of azacitidine activity in high-risk MDS and secondary AML. Leukemia. 2012;26(10):2297-9.
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Pallud J, Dezamis E, Audureau E, Devaux B, Souillard-Scemama R, Sanai N, Page P, Beuvon F, Koziak M, Oppenheim C, Dhermain F, Schlienger M, Meder J-F, Roux F-X, Varlet P. Neuronal immunoexpression and a distinct subtype of adult primary supratentorial glioblastoma with a better prognosis. J Neurosurg. 2012;117(3):476-85.
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Burgel P-R, Baixench M-T, Amsellem M, Audureau E, Chapron J, Kanaan R, Honoré I, Dupouy-Camet J, Dusser D, Klaassen CH, Meis JF, Hubert D, Paugam A. High prevalence of azole-resistant Aspergillus fumigatus in adults with cystic fibrosis exposed to itraconazole. Antimicrob Agents Chemother. 2012;56(2):869-74.
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Hardouin J-B, Audureau E, Leplège A, Coste J. Spatio-temporal Rasch analysis of quality of life outcomes in the French general population: measurement invariance and group comparisons. BMC Med Res Methodol. 2012;12:182.
2011
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Chaput U, Alberto SFolgado, Terris B, Beuvon F, Audureau E, Coriat R, Roche H, Gaudric M, Prat F, Chaussade S. Risk factors for advanced adenomas amongst small and diminutive colorectal polyps: a prospective monocenter study. Dig Liver Dis. 2011;43(8):609-12.
2010
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Audureau E, Merle V, Kerleau K, Dollois B, Baugé-Rousseau M, Théry S, Tavolacci M-P, Dubreuil N, Thillard D, Gasparin-Grisel S, Mathieu M, Augé C, Czernichow P. [Information for patients about hospital infections in psychiatry: An assessment of healthcare professionals' knowledge, opinion and attitude]. Encephale. 2010;36(2):132-8.
2009
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Audureau E, Deneux-Tharaux C, Lefèvre P, Brucato S, Morello R, Dreyfus M, Bouvier-Colle M-H. Practices for prevention, diagnosis and management of postpartum haemorrhage: impact of a regional multifaceted intervention. BJOG. 2009;116(10):1325-33.
2007
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Audureau E, Karmaly M, Daigurande C, Paris C, Evreux E, Thielly P, Pfister C. [Bladder cancer and occupation: a descriptive analysis in Haute Normandie in 2003]. Prog Urol. 2007;17(2):213-8.