Clinical Epidemiology and Ageing

Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients.

Nielsen L, Canoui-Poitrine F, Jais J-P, Dahmane D, Bartolucci P, Bentaarit B, Gellen-Dautremer J, Remy P, Kofman T, Matignon M, Suberbielle C, Jacquelinet C, Wagner-Ballon O, Sahali D, Lang P, Damy T, Galactéros F, Grimbert P, Habibi A, Audard V Br J Haematol. 2016;174(1):148-52.

<p>We performed a retrospective study to assess the changes in clinical, biological and heart echocardiographic parameters in 32 sickle cell disease (SCD) patients beginning haemodialysis. Acute SCD-related complications were similar at 6 months before and 6 months after the initiation of haemodialysis. Median haemoglobin level did not change significantly, but the need for blood transfusions increased (P < 0·001). The 5-year incidence of death was higher in SCD patients (P < 0·0001). The 5-year likelihood of receiving a renal graft was lower in SCD patients (P = 0·022). Our findings suggest that SCD patients have poorer survival and a lower likelihood of receiving a renal graft. </p>

MeSH terms: Adult; Anemia, Sickle Cell; Blood Transfusion; Cohort Studies; Female; Hemoglobins; Humans; Kidney Transplantation; Male; Morbidity; Mortality; Renal Dialysis; Renal Insufficiency, Chronic; Retrospective Studies; Young Adult
DOI: 10.1111/bjh.14040