Clinical Epidemiology and Ageing

Beclin-1 increases with obstructive sleep apnea severity.

Schlemmer F, Zysman M, Baptista BRibeiro, Audureau E, Noroc ACovali, Ridoux A, Derumeaux G, Adnot S, Maitre B, Le Corvoisier P, Lanone S, Boczkowski J, Boyer L Sleep Med. 2021;81:474-476.

Obstructive sleep apnea is a common chronic disorder that leads to chronic intermittent hypoxia described as an important factor contributing to the pathogenesis of OSA-related comorbidities. Besides, recent data suggest that intermittent hypoxia can induce adaptative cardiovascular pathways inducing a relative resistance to ischemic insults. Adaptative pathways induced by hypoxia could implicate autophagic processes and Beclin-1, one of the first mammalian autophagy effectors. Thus, activation of autophagy could protect against cardiovascular events in patients with OSA and could be considered as biomarker of a better prognosis.

MeSH terms: Animals; Autophagy; Beclin-1; Biomarkers; Humans; Hypoxia; Sleep Apnea, Obstructive
DOI: 10.1016/j.sleep.2021.03.017