Clinical Epidemiology and Ageing

[Cardiac amyloidosis].

Poullot E, Oghina S, Kalsoum S, Damy T Ann Pathol. 2021;41(1):25-37.

Different types of amyloid deposits involve the heart. Transthyretin and light chain amyloidosis are the most frequent. Diagnostic performance, typing and treatments have improved in the last decade, and prognosis of cardiac amyloidosis is now significantly better thanks to targeted therapies. In this article, we will describe the clinical manifestations of cardiac amyloidosis, the diagnostic approach and detail the characteristics and specific treatments of the most frequent types of cardiac amyloidosis. We will focus on the histopathological aspects, especially on the importance of amyloid typing.

MeSH terms: Amyloid; Amyloidosis; Humans; Prognosis
DOI: 10.1016/j.annpat.2020.11.010