Clinical Epidemiology and Ageing

Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer.

Lafont C, Paillaud E, Bertolus C, Baron M, Caillet P, Bouvard E, Laurent M, Salvan D, Chaumette L, de Decker L, Piot B, Barry B, Raynaud-Simon A, Sauvaget E, Minard A, Anota A, Panjo H, Brugel L, Canoui-Poitrine F J Natl Cancer Inst. 2024.

UNLABELLED: Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objectiveto assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC.EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score (EORTC QLQ-C30, QLQ-HN35) over 24 months.475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score.There is a need to develop alternative model of implementation such as patient-centered healthcare pathways.


DOI: 10.1093/jnci/djae027