cepia

Clinical Epidemiology and Ageing

[Optimizing the management of bladder cancer in older patients].

Neuzillet Y, Geiss R, Paillaud E, Mongiat-Artus P Prog Urol. 2019;29(14):849-864.

AIM: To define and present potential improvements for the management of bladder cancer in older patients.

METHOD: Bibliographical search was performed from the Medline bibliographic database (NLM Pubmed tool) and Embase focused on: bladder cancer, treatment, BCG, chemotherapy, cystectomy, and elderly.

RESULTS: The oncological principles of medico-surgical management of bladder cancer do not differ according to age. On the other hand, the patient comorbidities have been likely to alter the tolerance of these treatments. At the NMIBC stages, no adaptation of the standard treatment has demonstrated any interest. At the MIBC stages, the prognosis was improved by geriatric multidisciplinary perioperative management.

CONCLUSION: The indications and principles of surgical treatments must be identical regardless of the patient age. At the NMIBC stages, adjuvant therapy, including BCG therapy, should not be questioned because of the age of the patient. On the other hand, at the localized MIBC stages, neoadjuvant and adjuvant chemotherapy should not be considered as a standard and their indications assessed individually after geriatric assessment.

MeSH terms: Age Factors; Aged; Combined Modality Therapy; Humans; Urinary Bladder Neoplasms
DOI: 10.1016/j.purol.2019.08.273